Anti-Müllerian hormone (AHM) is relatively unfamiliar to most non-professionals. It is one of the transforming growth factors. It is mainly composed of immature cells of the male testis and pre-ovary sinus cells and small A glycoprotein secreted by granulosa cells of sinus eggs can be used as a key marker of female ovarian function. From the onset of female puberty, anti-Müllerian hormone will gradually decrease with age, and will remain at a detectable level before menopause, but will gradually disappear after menopause. After an in-depth study of anti-Müllerian hormone, it has been clinically found that it can be used to evaluate women’s ovarian reserve function, and can also be used to measure the age of menopause and as the main basis for judging ovarian insufficiency. Therefore, the clinical application value of anti-Müllerian hormone is self-evident, so who should be tested for anti-Müllerian hormone? How to detect it?
Who needs to be tested for anti-Müllerian hormone
In terms of the nature of anti-Müllerian hormone itself, many fields in clinical need to measure this hormone level for the diagnosis of the disease and the formulation of subsequent treatment plans.
(1) Application in assisted reproductive technology
Some couples with childbearing difficulties may consider adopting IVF to usher in a new life, but in the process of IVF treatment, anti-Müllerian hormone can be used as an important indicator to predict ovarian response, and then Develop an ovulation promotion program and consider the amount of medication. The specific anti-Müllerian hormone level has been clarified in the clinical judgment process to determine the ovarian response. For example, anti-Müllerian hormone less than or equal to 0.5ng/ml indicates that the ovarian response is low, and the number of egg cells obtained may be less than or equal to 4. In the case of low ovarian response, doctors need to discuss the problem of shortening the fertility window with the patient, so as to develop a special ovulation promotion plan. The ovarian response is within the normal range. These people can choose a standard agonist or antagonist program, and then formulate an effective ovulation induction program and the dosage of ovulation drugs according to the individual’s situation. High ovarian response indicates that there is a risk of overstimulation of the ovaries. These people should use a milder stimulation program to reduce the risk. For example, antagonists or clomiphene mild stimulation programs can be used.
(2) Preservation of fertility
Anti-Müllerian hormone is of great value to young women with malignant tumors, and to assess their fertility before and after treatment. In the course of clinical treatment, although the use of chemotherapeutic drugs with gonad toxicity and pelvic radiotherapy may have a curative effect on the malignant tumor of young patients, the damage caused by reproductive function is irreversible, so test tube hormones can be used to evaluate the treatment Before and after the change of ovarian function, we can consult the preservation of fertility on this measurement result and make a treatment prediction. Clinical studies have shown that before radiotherapy, patients with higher anti-Müllerian hormone will recover this hormone value faster after the end of chemotherapy.
(3) Judgment of ovarian syndrome
Since polycystic ovary syndrome is affected by anti-Müllerian hormone during the onset of the disease, there is a high correlation between the two, which can be used for the diagnosis of polycystic ovary syndrome. In the clinical diagnosis of women with polycystic ovary syndrome, the anti-Müllerian hormone value can be used to make judgments, and the sensitivity can be as high as 90% or more. At the same time, the test results of this hormone can also be applied to patients with polycystic ovary Ovulation induction dose design.
How to test anti-Müllerian hormone
When testing anti-Müllerian hormones, first of all, you need to go to the hospital for the first registration on the day of testing. Testing for Müllerian hormones does not require an empty stomach, nor will it be affected by women’s menstrual cycle, pregnancy or daily medication. Changes, the hormone concentration measurement at any time is relatively stable. After registration, the medical staff will measure the height, weight and blood pressure of the tester, make a preliminary understanding of the basic physical conditions, and then conduct the first face-to-face consultation with the doctor. They will probably be asked about the patient’s life history, menstrual history and Fertility history, etc. The actual test process needs to draw about two milliliters of blood, and the test results can be obtained about three hours after the test. After the blood draw is completed, the patient needs to perform a more comprehensive examination with two-dimensional color Doppler ultrasound. During this examination, the number of sinus follicles can be seen. The doctor will specifically determine whether the number of sinus follicles is within the normal range, generally more than 5 on each side. normal. After the test item is completed, you can get a checklist of anti-Müllerian hormone after a short wait. If the female friends who find that the estrogen level is in the lower range during the testing process do not have to worry too much, as long as the body conditioning is targeted, it is necessary to maintain good living habits, which is very important for the ovarian conditioning Try to stay away from all kinds of pollutants in daily life to ease the pressure in life.