Globally, the incidence of prostate cancer is on the rise, and it has become the second most common cancer in men. The National Cancer Institute of the United States lists age, family history, and the content of vitamin E, folic acid and calcium in the body as risk factors for the disease. Lifestyle is not involved. Recently, a large-scale study in the UK showed that lack of exercise is significantly related to the incidence of prostate cancer.
An international joint research team composed of institutions such as the University of Bristol and Imperial College London used the “Mendelian Randomization” method to investigate 22 risk factors for prostate cancer. The researchers compared the medical information of 79,000 participants with prostate cancer and 61,000 healthy participants and found that the participants with “active” gene mutations exercised more than normal people, and they suffered The risk of upper prostate cancer is 51% lower than those who do not carry this genetic variant. The research conclusions were published in the recently published “International Journal of Epidemiology”.
Sarah Lewis, the lead author of the study and a PhD in genetic epidemiology at the University of Bristol School of Medicine, pointed out that the so-called “exercise” is not limited to physical exercise, it can include all forms of physical activity, so encouraging men to increase their physical activity may prevent Prostate cancer plays a positive role. Ana Dias Font, director of Cancer Research UK, said that in the next step they will continue to use this method to explore the impact of other lifestyle factors on prostate cancer.
Berberine can reduce colorectal adenoma recurrence
Recently, the international academic journal “The Lancet·Gastroenterology and Hepatology” published online a research paper led by Fang Jingyuan’s team at the Department of Gastroenterology, Renji Hospital, Shanghai Jiaotong University School of Medicine. The study confirmed that berberine (berberine), an extract of Chinese medicine berberine, has a certain effect on preventing the recurrence of colorectal adenomas after resection.
Colorectal cancer is a common malignant tumor. About 90% of colorectal cancers originate from colorectal adenomas. Resection of colorectal adenoma under colonoscopy can prevent colorectal cancer, but the recurrence rate is more than 30% in 1 year after resection, and the recurrence rate in 3 years is about 50%. Internationally, chemical drugs to prevent the recurrence of colorectal adenomas have been developed, but they are difficult to popularize because of side effects or high prices.
Fang Jingyuan’s research team included patients who had recently diagnosed adenomas and had all adenomas removed, and randomly assigned the patients to the berberine group at a ratio of 1:1 through block randomization (twice a day, 0.3 grams each time ) And placebo group. Patients should complete at least one colonoscopy during the follow-up period until a recurrence of the adenoma is diagnosed or the last enrolled patient reaches the two-year follow-up point. Among the 891 patients who completed the follow-up, 155 patients (36.1%) in the berberine group and 216 patients (46.8%) in the placebo group had adenoma recurrence during the follow-up period; 183 patients (42.7 in the berberine group) %) Recurrences were polyps (including adenomas and serrated lesions). There were 255 cases (55.2%) in the placebo group. There were 15 cases (3.5%) and 26 cases (5.6%) in the two groups who recurred as high-risk progressive adenomas. This study shows that taking berberine can safely and effectively reduce the risk of colorectal adenoma recurrence.
This large-scale randomized, double-blind, placebo-controlled clinical trial study was led by Renji Hospital, Shanghai Jiaotong University School of Medicine, the Seventh Medical Center of PLA General Hospital, Tianjin Medical University General Hospital, Southern Medical University Nanfang Hospital, Xiamen The Department of Gastroenterology, Zhongshan Hospital Affiliated to the University, Drum Tower Hospital Affiliated to Nanjing University School of Medicine, and Shanghai Tenth People’s Hospital Affiliated to Tongji University were jointly completed. Fang Jingyuan’s team also proved that taking folic acid can prevent the occurrence of colorectal adenoma in people over 50 years old.