Human early migration alters immune-related genes

  A new study by South African biologists found that early human migration on the African continent changed the DNA and protected Africans from diseases and viruses. The study analyzed the whole genomes of 426 people from 13 African countries, whose ancestors represented 50 ethnic language groups from the entire African continent. The research results have been published in the latest issue of the journal Nature.
  The research was led by Professor Lombard from the Human Genetics Department of the Sidney Brunner Institute of Molecular Biosciences at the School of Health Sciences at the University of South Africa. The members include researchers from 24 institutions in Africa. Researchers have discovered 62 previously unreported genes related to virus immunity, DNA repair, and metabolism in the Bantu-speaking population.
  Lombard introduced that thousands of years ago, mankind began to move from Chad and Nigeria to East Africa, Central Africa and Southern Africa. Analytical data shows that judging from the genetic characteristics of the different populations currently living in these countries, most of the human migration has passed through Zambia. The heavy rain forest separates West Africa from Southern Africa, and migration in this area is not always clear. Genetic data shows similarities between the different groups currently living in West Africa and Zambia.
  Researchers have discovered more than 100 genomic regions that have been naturally selected, and a large part of them are related to immune-related genes that may help Africans fight disease. Dr. Seguta, who participated in the research work, said that for a long time, people have been actively looking for genes related to resistance to insect-borne diseases such as malaria and sleeping sickness, but our research shows that viral infections can help change people by changing gene frequencies. Genomic differences between the population and the population, thereby affecting individual susceptibility to disease.