Alzheimer’s disease and Parkinson’s disease have become the third largest “health killers” among middle-aged and elderly people after tumors and cardiovascular and cerebrovascular diseases. Hypertension, hyperlipidemia, hyperglycemia, hyperuricemia, and hyperhomocysteinemia are often infested by many “high” risk roles, especially hyperhomocysteinemia. So, what exactly is homocysteine? When people are old, can they maintain normal thinking, and how can they avoid falling into the “quagmire” of stupidity?
In response to the hot topics that the general public is concerned about, the member of the Neurovascular Intervention Collaborative Group of the Neurology Branch of the Chinese Medical Association, the vice chairman of the Stroke Academic Working Committee of the Education Branch of the Chinese Geriatrics Association, the chairman of the Stroke Branch of the Heilongjiang Integrative Medicine Association, Harbin Professor Zhang Zhuobo, director of the Department of Neurology of the Fourth Affiliated Hospital of Medical University, made a detailed interpretation for the readers.
Zhang Zhuobo said that homocysteine (Hcy) is a sulfur-containing amino acid in the blood that is damaging to blood vessels. disease” (high Hcy). According to the 2019 edition of my country’s “Hyperhomocysteinemia Diagnosis and Treatment Guidelines”, the incidence of “high Hcy” in the world is 5% to 7%, and the incidence in my country is as high as 27.5%, far exceeding that of some developed countries. The incidence is higher in northern regions and coastal areas. Due to the high Hcy, the prevalence of Alzheimer’s disease at home and abroad has exploded, and it has become a major public health problem that seriously affects the health and quality of life of the global population.
Cognitive impairment, the mastermind behind the scenes was uncovered.
Previously , the “China Stroke Primary Prevention” issued by the National Brain Prevention Commission has also identified “H-type hypertension” (hypertension combined with high homocysteine) as stroke important risk factors.
Zhang Zhuobo explained that the key to cognitive impairment and the formation of dementia is the loss of neurons, resulting in local brain atrophy and insoluble protein deposition. Studies have found that “high Hcy” produces neurofibrillary tangles and amyloid plaque substances that cause neurons to die. The experimental results show that the long-term “high Hcy” state will lead to the involvement of cerebral artery endothelial cells, the proliferation of arterial wall smooth muscle, the increase of platelet adhesion, the viscosity of blood, and the premature hardening, which in turn induces coronary heart disease, cerebrovascular disease, and Alzheimer’s disease. , diabetes and other diseases.
Zhang Zhuobo pointed out that Hcy is metabolized from chicken, duck, and fish that people eat daily, and these foods contain methionine. Under normal circumstances, the human body can decompose methionine into Hcy. At this time, if there are enough vitamin B groups such as vitamin B2, vitamin B6, vitamin B12, and folic acid coenzyme to participate in the catalysis, Hcy can continue to be decomposed into benign substances, such as glutathione. Glycide, S-adenosylmethionine, etc. These chemicals have antioxidant, anti-aging, anti-depressant and liver protection effects. If the above-mentioned B vitamins are lacking in the body, Hcy cannot be decomposed and accumulates in the human body, manifesting as “high Hcy”, which reduces the methylation and antioxidant capacity in the body, destroys the biochemical balance of the human body, and fundamentally shakes the foundation of health. .
A balanced diet helps to seek advantages and avoid disadvantages
How to prevent “high Hcy”? Zhang Zhuobo reminded that people must eat more fresh fruits and vegetables and balance their nutrition while enjoying big fish and meat and delicacies from mountains and seas, so as to avoid excessive Hcy in the blood. In this regard, the following suggestions are given in terms of diet:
First, eat less fatty meat and more soybean products, such as tofu, soy milk, bean skin, etc.;
second, pay attention to low-salt diet, instant noodles, ham, pickles, chili sauce, bean paste, etc. The invisible salt in processed foods should be highly vigilant;
the third is to drink less strong tea and coffee, and control the amount of alcohol;
the fourth is to eat more foods rich in vitamin B2, vitamin B6, vitamin B12, folic acid, zinc and magnesium, which can effectively reduce Hcy metabolism content, reducing the accumulation in the body;
Fifth, eat more cod, hairtail, salmon, sardines, pecans, walnuts, flaxseed, flax oil, perilla oil, hemp oil, etc. to inhibit chronic arterial inflammation, curb Hcy levels, and prevent cardiovascular and cerebrovascular diseases. It is a timely supplement of high-efficiency dietary supplements, such as active folic acid, vitamin B2, vitamin B6, vitamin B12, as well as zinc and betaine.