The more adverse reactions = the less secure the drug?

“There are a lot of bad reactions, and it’s scary.”

  Now, the people are more cautious in taking medicine than in the past. In the outpatient clinic, patients and friends often ask: “Doctor, can you recommend some Chinese medicines to replace Western medicine such as aspirin and atorvastatin?” If you ask further: “Why should I change the medicine?” Patients often answer: “Chinese medicine The toxicity is small. Western medicine has long suffered from liver injury and kidney damage.”
  Of course, some patients will also list a bunch of evidence: “If you look at the instructions for these joint ventures or imported drugs, the adverse reactions are fascinating. The instructions for our proprietary Chinese medicines are simple and straightforward, and the adverse reactions are often few and not serious. The
  more common situation is that the patient stopped taking the medicine because of fear and said: “This was the clinic doctor gave me yesterday. Medicine, I went back to read the instructions carefully, my God, the adverse reactions below wrote a lot of dense, what gastrointestinal reactions, may also hurt the liver and kidney, leading to insomnia, constipation, etc. Eat this medicine will not cure And what other problems
  have arisen ?” Then, a question that everyone is generally concerned about is: Is the more adverse the adverse drug reactions recorded, the less secure it is?
  There is a saying in the art of warfare that “knowing oneself and knowing oneself, and fighting for nothing.” In layman’s terms, it is to thoroughly understand each other to ensure that they are unbeaten. In the case of medication, this is also the reason: the more fully understood a drug, the more detailed the description or list of adverse reactions, the more we can fully grasp the safety of the drug, and it is more reliable to use. Therefore, the correct answer is: the more detailed the adverse reactions of a drug, the more detailed the drug is, the safer it is. Of course, we also need to understand the following two points:
1. What is an adverse drug reaction?

  Adverse reactions are those (possibly harmful) reactions that are not related to the purpose of treatment in a normal dosage (using the correct method of use) for a qualified drug (not a counterfeit or inferior drug). In general, all drugs are more or less, or light or heavy adverse reactions. This is an inherent property of medicines.
  Simply put, the occurrence of most adverse drug reactions is a probabilistic event, just like buying a lottery ticket: whether you can win a prize or not, there is no way to predict. We know that there will be some adverse drug reactions, but it is impossible to predict who will take adverse reactions, and it is impossible to predict what kind of adverse reactions will occur after taking the drug.
  Therefore, when a patient asks “Is this drug the first time I use it, what adverse reactions will occur after taking it? Is there any adverse reaction?” and other similar questions, we usually can’t answer. But we will tell him: “The adverse reactions listed in the instructions may or may not appear on you. The only thing you can do is to pay close attention to whether there are new or abnormal changes after taking the medicine. If it does, this may It is an adverse reaction, but also ask the pharmacist to help you confirm.”
2. How did the adverse reaction information come from?

  The main sources are: (1) studies conducted on drugs prior to marketing, including adverse reactions found in studies of animals (rats, mice, dogs, monkeys, etc.) and healthy subjects. (2) All relevant adverse events collected after thousands of patients have been used after the drug is marketed.
  The collection channels for adverse drug reactions in developed countries are relatively complete, and different participants will actively report: (1) Drug manufacturers actively collect, evaluate and report. (2) The medical institution will report it on its own initiative. (3) The patient’s voluntary reporting system. Therefore, after the drug is marketed, after the use of thousands of patients, the patient personally reports the adverse reactions encountered, and the responsible manufacturer or doctor continuously collects, summarizes, and evaluates. Once confirmed, it is added to the manual, so that Other patients have a reference for similar adverse reactions, and also let doctors have a more detailed understanding of the possible adverse reactions of this drug, knowing what kind of adverse reactions “may” occur after taking this drug. Therefore, many joint ventures or imported drugs, the adverse reactions are often listed as comprehensive, a large number of forests.
  Due to the lack of drug supervision in history, some of the “adverse reactions” in the instructions for proprietary Chinese medicines in our country have been blank for decades. There are no additions and changes, and it is often “not clear”. In this case, the drug producer does not understand the toxic side effects of the drug, and the drug prescribe is largely unaware of the possible adverse reactions after taking the drug. The drug use manager (pharmacist) also has no detailed adverse reaction data. . How can such “three unknown” drugs ensure the safety of drug users?
  However, many of our patients who believe in Chinese medicine, after taking the proprietary Chinese medicine prescribed by Western doctors, are very practical. In fact, the view that Chinese medicine is “non-toxic and harmless” is wrong. Recently, the state requires that Western doctors must pass the Western-Chinese system training and pass the examination before they can issue proprietary Chinese medicines or decoction pieces. This will help reduce adverse drug reactions and reduce the medical burden on patients.

Know what the worst outcome is, and avoid losing it.

  For a specific drug, although the medical staff can not accurately predict whether an adverse reaction will occur after a person takes the drug, and what kind of adverse reactions will occur, the medical staff can roughly understand the adverse reactions of the drug and know the adverse reactions. What are the most serious consequences, weigh the pros and cons for the patient to use. For example, an anti-tumor drug may cause serious hair loss, gastrointestinal mucosal erosion and other adverse reactions after use. However, in order to prolong the patient’s life, the doctor will use the patient after weighing the pros and cons, because adverse reactions such as hair loss can be tolerated and prolonged relative to prolonging life. However, if it is used to treat mild skin allergies, the drugs taken can cause diarrhea, hair loss, etc., we will feel that the drug is not worth the loss, it will not be used.
  This is why we need to understand the adverse reactions of a drug as comprehensively as possible. The more complete and complete the information, the more confident we are, the more assured we are. The general public should keep in mind that adverse reactions occur, have certain probabilistic characteristics, and the adverse reactions listed in the instructions may appear on you, and the greater may not appear on you. Even if it occurs, timely medical treatment can avoid serious consequences.