Dog medicine fights cancer, how beautiful legends shine into reality

  When a person is diagnosed with a malignant tumor, it means being sentenced to death. At this time, he will be willing to try any kind of life-saving method. The anti-cancer story of canine drugs circulating on the Internet in the past two years is a good proof.
Dog medicine enters the public eye

  In the winter of 2016, American elderly Joe Tippens was diagnosed with small cell lung cancer. Upon hearing this bad news, Tippens immediately went to MD Anderson Hospital, the world’s recognized authoritative oncology hospital, but the doctors there said that they could do nothing. In January 2017, cancer cells have spread throughout his body. The chest oncologist told Tippens that he could undergo a clinical trial and that although his life could not be saved, the best situation could extend his life span. It’s better than nothing, and Tippens is happy to accept it.
  A few days later, Tippens met a vet at a forum at the University of Oregon. The vet told Tippens that a scientist at the Merck Animal Health Institute found in the experiment that an anthelmintic drug taken by a dog could cure cancer. The scientist was diagnosed with stage 4 brain cancer, and he chose to take the insecticide called fenbendazole for less than three months. After 6 weeks, the cancer cells in his body disappeared.
  When the dead horse became a living horse doctor, Tippens decided to start taking fenbendazole. He used a “prescription” containing fenbendazole: canine drug (1 g per day for 3 days, 4 days off); vitamin E (400 mg to 800 mg per day, 7 days per week); biodigestible curcumin (600 mg per day, 7 days a week, 2 capsules per day); CBD oil (ie, cannabidiol, 25 mg per day under the tongue, 7 days a week). After 3 months of continuous dosing, the PET scan of Tippens showed that the cancer cells all disappeared.
  This result made the oncologist stunned. Doctors say that Tippens is the only patient who has lost cancer in clinical trials. Therefore, Tippens is convinced that the dog medicine has cured his cancer. After the story of Tippens’ successful anti-cancer has spread to China, some Chinese cancer patients have chosen to try this treatment. However, at present, this treatment has not been officially used and promoted in hospitals. Is dog medicine an effective and reliable anti-cancer method?
Does have the potential to cure certain cancers

  Since 1999, scientists have conducted research on the efficacy of fenbendazole on cancer. Many studies have shown that fenbendazole has anticancer effects.
  A study published in the June 2018 issue of Science Report found the possible principle of fenbendazole against cancer. The researchers believe that fenbendazole can damage cellular protease function, destroy the metabolism of cancer cells, and thus inhibit cancer cell growth. Another article published in the June 2012 issue of the Journal of Biochemistry holds this view. At the same time, fenbendazole can also inhibit the uptake of glucose by cancer cells, which is equivalent to letting cancer cells go hungry to inhibit their growth. According to the study, fenbendazole can interfere with microtubule formation and affect multiple cellular pathways to achieve the above effects.
  Recently, studies have shown that fenbendazole can also treat cancer by increasing the expression of tumor suppressor genes. This study, published in the Molecule on June 7, 2019, showed that some cancers occur because the genes Mdm2 and MdmX, which inhibit the expression of the tumor suppressor gene P53, are overexpressed. This is equivalent to the excessive weakening of the police force that was originally used to maintain law and order in our bodies, which led to the bully being rampant but unable to suppress. Fenbendazole can improve the stability and transcriptional ability of P53, reduce the expression of Mdm2 and MdmX, inhibit cancer cells, and restore normal function of the human body.
  Since 2008, a number of experimental studies have demonstrated the efficacy of fenbendazole against cancer. In animal experiments, fenbendazole can treat canine glioma. An article in the Chinese Journal of Pathophysiology says that in human cell culture in vitro experiments, scientists used chronic myeloid leukemia cell K562 (a blood cancer cell) and normal human peripheral blood mononuclear cell PBMC for comparative experiments, using a variety of experiments. The method was used to detect the effects of fenbendazole on the growth, structure and function of the two cells. The results showed that fenbendazole significantly inhibited the growth of K562 cells, but had no significant effect on the growth of PBMC. Further studies have also found that fenbendazole can affect the mitosis of K562 cells, that is, it can not produce more cancer cells.
  Foreign researchers have also studied the effects of fenbendazole on mice transplanted with human lymphoma. They found that fenbendazole alone did not have anti-cancer effects, and only when combined with vitamins, can significantly inhibit tumor growth.
  We know that the three characteristics of malignant tumors are: immortalization, cell morphology and easy metastasis. According to the above research, fenbendazole can prevent the proliferation of cancer cells by cutting off its nutrient source, inhibiting the proliferation of cancer cells, and interrupting the proliferation of cancer cells. Losing the characteristics of unlimited proliferation, cancer cells can no longer be our opponents. As a result, fenbendazole may have the potential to treat cancer, and the case of Tippens being cured is not unfounded.
There are also “missing”

 Although there are many experimental reports showing that fenbendazole may be our new hope for cancer, there are some studies that fenbendazole does not have a role in treating cancer.
  A study published in Anti-Cancer in February 2013 showed that although fenbendazole is cytotoxic to EMT6 mouse breast tumor cells cultured in vitro, it has no effect on breast tumors grown in mice. . Therefore, the researchers believe that fenbendazole is of no value in cancer treatment.
  In the 1999 Toxicology Pathology, scientists even found that fenbendazole may have a role in promoting tumor growth in the liver. They fed two groups of mice with feeds containing various doses or no fenbendazole, and found that the liver of mice fed fenbendazole was significantly more abundant than that of mice without fenbendazole. Weight gain.
  Therefore, for dog drugs to fight cancer, we need to maintain a rational attitude. In the absence of a clear mechanism of action and insufficient clinical trials, we need to wait for further research and discovery.
More research is needed on the anticancer effect of canine drugs

  Fenbendazole belongs to the class of benzimidazoles, which are structurally similar and belong to microtubule-interfering drugs. Studies have shown that other members of these drugs may also have the potential to fight cancer. Among them, mebendazole is considered by scientists because of its good pharmacokinetics, and its anticancer mechanism is being further studied. Therefore, friends who are interested in canine drugs can also pay attention to the research progress of such drugs.
  The role of fenbendazole in combating cancer has only attracted attention in recent years. Until now, researchers have not been exposed to the anti-cancer effect of fenbendazole for a long time, the research is still not deep enough, the precipitation of relevant knowledge is not sufficient, and there is no formal scientific report for humans.
  We don’t know enough about the mechanism of this drug’s anti-cancer mechanism, and it is not clear about its possible effects on humans, side effects, and potential risks. As a result, this new and unfamiliar drug has not been used in hospital clinical practice. Compared with canine medicine, the more mature surgery, chemotherapy and radiotherapy are still the preferred method for cancer prevention.